Containment sampling system

Single-use technology

Containment sampling system

Name: Containment sampling system
Brand: HECHT Technology
Availability: PreOrder

Single-use technology

Description

HECHT's containment sampling system is a closed interface that takes samples directly from a process line without exposure to product or environment, essential for processes where product quality, operator safety and containment are paramount. Via a vacuum-sealed port, the operator connects a sterile container, after which the sample flows in a controlled manner, the container is disconnected and digitally logged — entirely without dust exposure or contamination risk, with less than 0.1% waste-to-air. The system is available in three capacities: Compact (up to 50 mL), Standard (up to 200 mL) and Plus (up to 500 mL, dual-port), and operation consists of just three steps (connect, sample, disconnect) with about 1 hour of training. Single-use sterile containers with interlocks are ready to use immediately, and the system is suitable for OEB 1-5 applications, GMP Annex 1 (2022) compliant and GAMP 5 validatable, with built-in FDA 21 CFR Part 11 sample logging.

Customer benefits

Maximum safety: no operator exposure to product
Product integrity: no process contamination
Reliable analysis: representative samples
Efficiency: sampling without process stoppage
Compliance: meets GMP and containment guidelines
Flexibility: applicable to existing installations

Frequently asked questions about the containment sampling system

What is a containment sampling system and why is dust-free operation important?

A containment sampling system is a closed interface for safe sample-taking. Dust-free operation is important because: (1) operator safety protected, (2) sample integrity guaranteed, (3) process contamination prevented, (4) direct OEB compliance.

How much dust exposure occurs during sampling?

<0.1% waste-to-air. Closed-system port. Dust-free transfer. Zero fugitive emission to the environment.

How does the sterile sample-taking technique work?

Vacuum-sealed port → operator connects sterile container → sample flows → container is disconnected → digital logging. Zero dust exposure. Zero contamination risk.

Is the containment system GMP compliant?

Yes. GMP Annex 1 (2022) compliant, GAMP 5 validation available. FDA 21 CFR Part 11 sample logging built-in. Validation: 2–3 weeks.

How much sample can be taken per cycle?

Compact: up to 50 mL. Standard: up to 200 mL. Plus: up to 500 mL (dual-port). Scalable to your monitoring volume.

How easy is the sample-taking technique?

Very easy. Three steps: connect → sample → disconnect. Training: 1 hour. No special skill required. Operator-safe.

Can the system handle OEB 4–5 activities?

Yes. OEB 1–5 compliant. Closed system with zero fugitive emissions. Dust-free sampling. Suitable for critical monitoring.

How are sterile containers managed?

Single-use sterile containers with interlocks. HECHT provides sourcing advice. Containers are sterilised and ready to use. Disposable flow integrated.

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Applications

Contained inline sampling systems are used in:

Pharmaceutical industry (APIs, HPAPIs, powders, liquids)
Chemical and fine chemical industry
Biotechnology (sterile and sensitive products)
Food industry (quality control)
Process validation and quality analysis

Sampling is a crucial step to guarantee process control and product consistency.

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Product overview

Contained inline sampling system – closed sampling from process equipment

The contained inline sampling system makes it possible to take a representative sample directly from a reactor, dryer, mixer or pipe without opening the process.

Operating principle:

A fixed sampling interface is mounted on the process plant
A closed sampling unit (e.g. bag or liner system with glove port) is connected
Sampling takes place in an enclosed environment
The sample is packed safely and disconnected for analysis

For example: a sampling bag with integrated glove and sample bottle is connected, after which the operator takes the sample without direct contact with the product.

Key features

Fully closed sampling (high containment level)
Direct sampling from the process (inline)
Suitable for powders and liquids
Minimises operator exposure (OEB/OEL compliant)
Representative, reproducible samples
Integration without process interruption
Single-use solutions possible (no cleaning needed)

Containment solutions

Depending on the application and containment level, different configurations are possible:

Single-use sampling systems

Disposable bags or liners
No cleaning or cleaning validation needed
Suitable for GMP environments

Glovebox sampling

Maximum operator protection
For highly toxic or high-potency substances

Split valves / closed couplings

Dust-free connection to process equipment
High level of process safety

Technologies and models

Depending on product properties and the required accuracy, different dosing principles are possible:

Vibrating dosing valves

Ensure an even product flow
Prevent bridging and lumping
Suitable for fine and poorly flowing powders

Butterfly or slide valves with dosing function

For controlled opening and closing
Suitable for both coarse and fine dosing

Flexible dosing systems (hose principle)

No mechanical parts in the product flow
Gentle and hygienic dosing
Very suitable for sensitive products

Processing options

Inline sampling from reactors, dryers and mixers
Sampling of powders, granules and liquids
Quality control during production (in-process control)
Sampling for laboratory analysis
Sterile sampling applications
Integration with PAT (Process Analytical Technology)

Key benefits

Maximum safety: no operator exposure to the product
Product integrity: no contamination of the process
Reliable analysis: representative samples
Efficiency: sampling without stopping the process
Compliance: meets GMP and containment guidelines
Flexibility: can be used on existing installations

Technical specifications (approximate)

Application: powders, granules, liquids
Containment: up to OEB 5 possible
Operation: batch and continuous
Integration: reactors, dryers, pipes, mixers
Material: stainless steel (316L), single-use polymers
Sampling: manual or semi-automatic

Options:

Single-use liners and sampling bags
ATEX version
CIP/SIP systems (for reusable systems)
Sterile sampling configurations
Automation and digital monitoring
Integration with isolators

Why choose Hecht Technology?

Hecht Technology specialises in containment and safe product handling and offers:

Tailor-made solutions for every containment level
Integration into existing and new process lines
Expertise in sampling, transfer and dosing
Support with GMP, ATEX and validation

Typical applications

In-process control of pharmaceutical production
Sampling of toxic or high-potency substances
Quality control in chemical processes
Sterile sampling in biotech applications
Product development and validation

Would you like more information?

Would you like to know which contained inline sampling system best suits your process and containment requirements? Contact our specialists for tailored advice.